Anion-controlled foldamers
نویسندگان
چکیده
منابع مشابه
Neutral iodotriazole foldamers as tetradentate halogen bonding anion receptors.
Neutral tetradentate halogen bond donor foldamers were synthesised and exhibit enhanced anion affinities over their hydrogen bonding analogues, displaying iodide selectivity over lighter halide, carboxylate and dihydrogen phosphate anions. A foldamer with a chiral (S)-binaphthol motif was demonstrated to distinguish between enantiomers of chiral anions.
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Introduction Oligo(m-phenyleneethynylene)s, shown in Figure 1, have been shown to undergo a solvent-driven transition from a random conformation in low polarity solvents to an α-helix conformation in polar solvents as a result of solvophobic interactions. 2 However, a detailed atomic-level study of the effects of specific intermolecular interactions, such as hydrogen bonding, van der Waals and ...
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Small arylamide foldamers designed to mimic the amphiphilic nature of antimicrobial peptides (AMPs) have shown potent bactericidal activity against both Gram-negative and Gram-positive strains without many of the drawbacks of natural AMPs. These foldamers were shown to cause large changes in the permeability of the outer membrane of Escherichia coli. They cause more limited permeabilization of ...
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Proteins and nucleic acids perform a wide range of complex functions in biological systems. Nearly all of these molecular operations require the biopolymer chain to adopt a compact and specific folding pattern. The conformational behavior of biopolymers is usually analyzed hierarchically: secondary structure reflects local features of the backbone (helix and sheet are the secondary structures w...
متن کاملA post-modification approach to peptide foldamers.
Hydrophilic/hydrophobic patterning is a powerful strategy to control folding in non-natural polymers/oligomers. In this contribution, we present a novel strategy for the preparation of alternating hydrophilic/hydrophobic patterned non-natural peptide foldamers. This strategy relies on the post-modification of a reactive peptide precursor that can be prepared via standard solid phase peptide syn...
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ژورنال
عنوان ژورنال: Chemical Society Reviews
سال: 2010
ISSN: 0306-0012,1460-4744
DOI: 10.1039/b926162c